|
KMID : 0617319930030010068
|
|
Journal of Pharmacetical Sceiences Ewha Womans University
1993 Volume.3 No. 1 p.68 ~ p.73
|
|
|
Ring Transformation Reaction of Thiazolo[3,2-a][1,3]diazepinium-Betaine
|
|
|
|
|
Abstract
|
|
|
|
3-Phenyl-5,6,7,8-tetrahydrothiazolo[3,2-α][1,3] diazepine, which has pharmaceutical activities, was reacted with phenyl isothiocyanate to give 3-phenyl-9-phenyl(thiocarbamoyl)-5,6,7,8-tet-rahydrothiazolo[3,2-α][1,3]diazepinium-betaine. New biheterocyclic compounds were prepared by the ring transformation reaction of the above reactive betaine with α-haloesters and α-haloketones such as ethyl bromoacetate, methyl bromoacetate, chloroacetone, and 4′-methoxyphenacyl bromide, respectively, In each ring transformation reaction, two major products supposed to be geometrical isomers were obtained.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|